ADC Control Human IgG1 kappa-vcMMAE is a human monoclonal antibody and an isotype control for Human IgG1 kappa-vcMMAE that inhibits tubulin polymerization.
体外活性
ADC Control Human IgG1 kappa-vcMMAE可在 CD30⁺癌细胞中从 SGN-35 有效释放,凭借其膜通透性发挥旁观者杀伤效应 [1]。
ADC Control Human IgG1 kappa-vcMMAE能够以时间与剂量依赖性方式,增强结肠癌细胞和胰腺癌细胞对放疗(IR)的敏感性,表现为克隆形成率降低、DNA 双链断裂增多 [2]。
存储条件
Store at low temperature
Store at -20°C
Shipping with blue ice/Shipping at ambient temperature.